Individualização da Imunossupressão em Pacientes Transplantados Renais.
Roberto Ceratti Manfro
Professor Adjunto. Faculdade de Medicina. Universidade Federal do Rio Grande do Sul.
Serviço de Nefrologia, Hospital de Clínicas de Porto Alegre. Porto Alegre, RS.
Endereço para correspondência: Roberto C. Manfro; Hospital de Clínicas de Porto Alegre. Serviço de Nefrologia, sala 2030, Rua Ramiro Barcelos 2350; Porto Alegre, RS. 90035-003; FAX: (51) 21018121 e-mail: rmanfro@hcpa.ufrgs.br
Referências Bibliográficas.
- Danovitch G. Immunosuppressive medications for renal transplantation: a multiple choice question. Kidney Int 2001; 59:388-402
- First R. Tailoring immunosuppressive therapy based on donor and recipient risk factors. Transplant Proc 2001; 33:2207-11
- de Mattos AM., Bennet WM, Barry JM, Norman DJ. HLA-identical sibling renal transplantation--a 21-yr single-center experience. Clin Transplant 1999; 13:158-67
- Land W, Schneeberger H, Weiss M, Ege T, Stumpfig L. Mycophenolate mofetil monotherapy: an optimal, safe, and efficacious immunosuppressive maintenance regimen in kidney transplant patients. Transplant Proc 2001; 33(4 Suppl):29S-35S
- Abramowicz D, Norman DJ, Vereestraeten P, Goldman M, De Pauw L, et al. OKT3 prophylaxis in renal grafts with prolonged cold ischemia times: association with improvement in long-term survival. Kidney Int 1996; 49:768-72
- Rengel M, Fernandez Rodriguez A, Gomez Huertas E, Plaza JJ, Ruiz San Millan JC. Immunoprophylaxis with Simulect (basiliximab) in kidney transplantation: results from routine clinical practice at 18 kidney transplant units. Transplant Proc 2003; 35:1691-3
- ter Meulen CG, van Riemsdijk I, Hene RJ, Christiaans MH, Borm GF. Am J Transplant, 2004. Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a prospective, randomized, multicenter study. Am J Transplant 2004; 4:803-10.
- Flechner SM, Goldfarb D, Modlin C, Feng J, Krishnamurthi V, et al. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. Transplantation 2002; 74:1070-6
- Hricik DE. Steroid-free immunosuppression in kidney transplantation: an editorial review. Am J Transplant 2002; 2:19-24
- Suwelack B, Gerhardt U, Hohage H. Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy.
Am J Transplant. 2004; 4:655-62
- Manfro RC. Protocolos de Imunossupressão. In: Manfro RC, Noronha IL, Pacheco-Silva Filho A. (eds) Manual de Transplante Renal. Manole, São Paulo, 2004.
- Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. New Engl J Med 2005: 353: 770-81
- Sarwal M, Chua MS, Kambham N, Hsieh SC, Satterwhite T, Masek M, Salvatierra O Jr. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125-38
- Aquino-Dias EC, Câmara NOS, Pacheco-Silva A, Manfro RC. Monitorização imunológica molecular da rejeição de transplantes renais. J Bras Nefrologia 2005;27:76-83
- Tinckam K, Rush D, Hutchinson I, Dembinski I, Pravica V, Jeffery J, Nickerson P.The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology. Transplantation 2005; 79: 836-41
